Background
Dementia is a general term for loss of memory, language, problem-solving, and other thinking abilities that are severe enough to interfere with daily life. Alzheimer’s disease is the most common type of dementia, accounting for 60-80% of dementia cases. It is progressive, beginning with mild memory loss, leading to the loss of ability to respond to the environment.
Dementia is caused by damage to brain cells that interferes with the ability of those cells to communicate with each other correctly. Scientists are working to determine the true cause of Alzheimer’s disease. They know that high levels of certain proteins inside and outside brain cells affect the way those cells talk to each other. Clinical trials are underway that focus on lowering these proteins in an effort to slow the progression of the disease.
Symptoms
Alzheimer’s disease is not a normal part of aging. Researchers believe there isn’t one cause, but that it likely develops from multiple factors, including genetics, lifestyle, and environment.
The most prominent symptom is difficulty with memory. In addition to memory issues, people with Alzheimer’s disease may experience one or more of the following additional symptoms:
- Trouble handling money and paying bills.
- Decreased or poor judgement.
- Changes in mood or personality.
- Misplacing items and being unable to retrace steps to find the item.
- Difficulty in remembering newly learned information.
- Memory loss that leads to repeating the same question or getting lost in familiar places.
Risk Factors
There are risk factors that play a part when determining if a person has Alzheimer’s:
- Age: Most people with the disease are 65 and over, although some people are diagnosed at a younger age. After age 65, the risk for Alzheimer’s doubles every 5 years.
- Family History: Those who have a parent or sibling with the disease are more likely to develop Alzheimer’s themselves.
- Genetics: There are certain genes that are known to be related to Alzheimer’s. While genetic testing is available to evaluate for these genes, these types of tests are cautioned against until a person has had proper counseling and understands the information. Your doctor can help you decide if genetic testing would be beneficial.
Diagnosis
There is not one specific test to determine if someone has Alzheimer’s disease. Doctors diagnose Alzheimer’s and other types of dementia based on the patient’s medical history, lab tests, and memory function evaluations. To get a more accurate diagnosis, a person may need to get images of their brain (MRI, CT, PET scan) or a test done on their cerebrospinal fluid, the fluid that cushions the brain.
It is important to contact a doctor if you suspect that you or a loved one is showing signs of dementia. Your provider can help determine if the symptoms are related to dementia or something else, like a vitamin deficiency or a side effect from a medication. Early intervention can also open the door to more opportunity for you and your family to consider future plans, enroll in clinical trials, and anticipate financial needs.
Treatment Goals
The main treatment goal for a person with Alzheimer’s disease is to improve their quality of life. There is currently no known cure for this disease. However, interventions are available that can help with maintaining brain health, managing symptoms, and slowing or delaying progression of the disease.
There are different types of medications approved for Alzheimer’s disease. Your doctor will work with you to decide if treatment would be beneficial and what type of medication would be the best therapy for you.
Cholinesterase Inhibitors & Side Effects
Examples: Aricept (donepezil), Exelon (rivastigmine), Razadyne (galantamine).
These medications are approved for the symptomatic management of mild to severe disease. Patients may see small improvements in cognition and activities of daily living with these medications. However, these drugs do not prevent or delay progression of the disease.
Common Side Effects:
- Nausea
- Diarrhea
- Vomiting
- Headache
- Anorexia
- Muscle cramps
- Atopic dermatitis
NMDA Receptor Antagonists & Side Effects
Examples: Namenda (memantine).
These medications are approved for the symptomatic management of moderate to severe Alzheimer’s disease and can be used in combination with cholinesterase inhibitors. These drugs do not prevent or delay the progression of the disease.
Common Side Effects:
- Headache
- Dizziness
- Confusion
- Constipation
- Hypertension
Anti-Amyloid Agents & Side Effects
Examples: Leqembi (lecanemab).
This class of drug is approved to help treat people with Alzheimer’s disease with mild cognitive impairment or mild dementia. This is the only class to have shown evidence of reducing clinical decline.
Common Side Effects:
- Headache
- Infusion-related reactions
- Amyloid-related imaging abnormalities (ARIA
Resources
https://www.cdc.gov/alzheimers-dementia/
https://www.cdc.gov/alzheimers-dementia/signs-symptoms/alzheimers.html
Support
https://www.alz.org/help-support
https://www.alz.org/events/event_search